协和医学杂志

2012, (01)

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骨促结缔组织增生性纤维瘤的临床病理分析
Clinicopathological study on desmoplastic fibroma of the bone

师杰;常晓燕;崔全才;姜英

摘要(Abstract):

目的 探讨骨促结缔组织增生性纤维瘤的临床表现、病理形态特征及鉴别诊断要点。 方法 报告4例骨促结缔组织增生性纤维瘤并进行了组织形态学、免疫组织化学研究,结合文献对其临床表现、病理形态特点及鉴别诊断进行探讨。 结果 骨促结缔组织增生性纤维瘤病变由梭形细胞(纤维母细胞/肌纤维母细胞)构成,背景是丰富的胶原纤维,有程度不等的玻璃样变。细胞数量不等,没有或仅有轻度的细胞不典型性和多形性,少见核分裂象。结论 骨促结缔组织增生性纤维瘤是一种罕见的良性骨肿瘤,呈进行性、侵袭性,有时复发。
Objective To investigate the clinicopathological features and differential diagnosis of solitary desmoplastic fibroma of the bone (DF). Methods 4 cases of DF were reported. Based on light microscopic observation, an histochemical study was carried out. Their clinical manifestations, pathologic features and main point of differential diagnosis were discussed, and literature was reviewed. Results DF was composed of spindle cells (fibroblasts/ myofibroblasts) in a background of numerous thick and wavy collagen fibers of ovoid nuclei dispersed within a collagenous fibers. Lack of mitotic figures, hypercellularity and pleomorphism. Conclusions DF was a rare benign lesion with good progression and sometimes recurred.

关键词(KeyWords): |骨 促结缔组织增生性纤维瘤|
|Bone Desmoplastic fibroma|

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作者(Author): 师杰;常晓燕;崔全才;姜英

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