协和医学杂志

2012, (01) 47-50

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骨促结缔组织增生性纤维瘤的临床病理
Clinicopathological Features of Desmoplastic Fibroma of the Bone

姜英;常晓燕;师杰;崔全才;
JIANG Ying,CHANG Xiao-yan,SHI Jie,CUI Quan-cai Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

摘要(Abstract):

目的探讨骨促结缔组织增生性纤维瘤的临床表现、病理形态特征及鉴别诊断要点。方法报告4例骨促结缔组织增生性纤维瘤并进行组织形态学、免疫组织化学研究,结合文献对其临床表现、病理形态特点及鉴别诊断进行探讨。结果骨促结缔组织增生性纤维瘤病变由梭形细胞(纤维母细胞/肌纤维母细胞)构成,背景是丰富的胶原纤维,有程度不等的玻璃样变。细胞数量不等,没有或仅有轻度的细胞不典型性和多形性,少见核分裂象。结论骨促结缔组织增生性纤维瘤是一种罕见的良性骨肿瘤,呈进行性、侵袭性,有时复发。
Objective To investigate the clinicopathological features of solitary desmoplastic fibroma of the bone(DF).Methods Totally 4 cases of DF were confirmed in our hospital from October 2004 to July 2008.Their clinical manifestations as well as the pathologic,morphologic,and immunohistochemical findings were summarized,and relevelant literature was reviewed.Results DF was composed of spindle cells(fibroblasts/myofibroblasts) in a background of numerous thick and wavy collagen fibers of ovoid nuclei dispersed within a collagenous fibers.No mitotic figures,hypercellularity,or pleomorphism was observed.Conclusion DF is a rare benign lesion and can be progressive,invasive,and sometimes recurrent.

关键词(KeyWords): 骨,促结缔组织增生性纤维瘤;临床病理
bone,desmoplastic fibroma;clinicopathology

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作者(Author): 姜英;常晓燕;师杰;崔全才;
JIANG Ying,CHANG Xiao-yan,SHI Jie,CUI Quan-cai Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China

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