协和医学杂志

2012, (01)

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肝细胞异型增生结节的临床病理
Clinicopathological Observation on Hepatocellular Dysplastic Nodules

梁智勇;周炜洵

摘要(Abstract):

目的 探讨肝细胞异型增生结节的病理特点及诊断要点。方法 收集12例肝细胞异型增生病例,总结、分析其病理改变及临床资料。 结果 肝细胞异型增生多为肉眼能识辨的结节,以增生的肝细胞密度增加、核/浆比增高为特点,可以伴有肝细胞排列紊乱及非配比小动脉的出现。2例病例出现早期肝细胞肝癌的表现。临床随诊7例切除后无再发,1例48个月后发生肝癌。结论 肝细胞异型增生结节病理形态学有其特点,与肝细胞肝癌关系密切,是肝细胞肝癌的癌前病变。
Objective To discuss the clinicopathological characteristics of hapatocellular dysplastic nodules. Methods 12 cases of hepatocellular dysplastic nodules were collected and their clinical and pathological features were reviewed. Results Hepatocellular dysplastic nodules are nodules on gross examination. On microscopic examination, they appear increased cell density as well as nucleus / cytoplasm ratio. Structural atypia and unpaired arteries can also be found. In 2 cases there were foci of early hepatocellular carcinoma in dysplastic nodules. With follow up, 7 patients live without tumors, and 1 case developed hepatocellular carcinoma after 48 months. Conclusion Histopathology of hepatocellular dysplastic nodules is characteristic and it is the precursor of hapatocellular carcinoma.

关键词(KeyWords): |肝疾病|异型增生|诊断|
|liver diseases| dysplastic| diagnosis|

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作者(Author): 梁智勇;周炜洵

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