协和医学杂志

2020, (06) 698-702

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原发性皮肤淋巴瘤WHO-EORTC分类最新进展解读
WHO-EORTC Classification of Primary Cutaneous Lymphomas: Updates and Interpretation

刘洁;罗毅鑫;刘兆睿;刘跃华;张薇;卢朝辉;
LIU Jie;LUO Yi-xin;LIU Zhao-rui;LIU Yue-hua;ZHANG Wei;LU Zhao-hui;Department of Dermatology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Dermatology, Leiden University Medical Center;Department of Hematology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Pathology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Uni

摘要(Abstract):

原发性皮肤淋巴瘤(primary cutaneous lymphoma,PCL)是一类结外非霍奇金淋巴瘤,具有独特的临床表现和组织病理学特征。2005年世界卫生组织-欧洲癌症研究和治疗组织(World Health Organization-European Organization for Research and Treatment of Cancer,WHO-EORTC)发表的PCL分类是该病的重要诊断标准和分类依据。随着研究进展,2018年WHO-EORTC更新了PCL分类,新增了慢性活动性EB病毒感染、原发性皮肤肢端CD8~+T细胞淋巴瘤、EB病毒阳性皮肤黏膜溃疡3种PCL类型,并对部分PCL的亚型进行了修订,其中涉及淋巴瘤样丘疹病、原发性皮肤边缘区淋巴瘤、原发性皮肤CD4~+小/中T细胞淋巴组织增殖性疾病等亚型。本文对PCL WHO-EORTC分类的最新进展进行解读。
Primary cutaneous lymphomas(PCL) are a group of non-Hodgkin's lymphomas that are presented with specific clinical manifestations and histopathological characteristics. The classification of PCL published by World Health Organization-European Organization for Research and Treatment of Cancer(WHO-EORTC) in 2005 was the important diagnostic criteria and classification basis for cutaneous lymphomas. With research progression, WHO-EORTC updated the classification of PCL in 2018, adding three subtypes of PCL, namely, chronic active Epstein Barr virus(EBV) infection, primary cutaneous acral CD8~+ T-cell lymphoma, and EBV-positive mucocutaneous ulcer. Besides, some subtypes of PCL were revised, including lymphomatoid papulosis, primary cutaneous marginal zone lymphoma, and primary cutaneous CD4~+ small/medium T cell lymphoproliferative disease. This article interprets the update of WHO-EORTC classification of PCL.

关键词(KeyWords): 原发性皮肤淋巴瘤;T细胞淋巴瘤;B细胞淋巴瘤;结外NK/T细胞淋巴瘤
primary cutaneous lymphoma;T-cell lymphoma;B-cell lymphoma;extranodal NK/T-cell lymphoma

Abstract:

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基金项目(Foundation): 国家重点研发计划资助项目(2016YFC0901500);; 北京市自然科学基金(7182127)~~

作者(Author): 刘洁;罗毅鑫;刘兆睿;刘跃华;张薇;卢朝辉;
LIU Jie;LUO Yi-xin;LIU Zhao-rui;LIU Yue-hua;ZHANG Wei;LU Zhao-hui;Department of Dermatology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Dermatology, Leiden University Medical Center;Department of Hematology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College;Department of Pathology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Uni

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